Quinidine Thiourea‐Catalyzed Aldol Reaction of Unactivated Ketones: Highly Enantioselective Synthesis of 3‐Alkyl‐3‐hydroxyindolin‐2‐ones

Abstract

Enolat statt Enamin: Die asymmetrische Aldolreaktion nichtaktivierter Ketone mit aktivierten Carbonylverbindungen läuft in Gegenwart eines Chinidin-Harnstoff-Katalysators (siehe Schema) über einen Enolatmechanismus ab, und nicht über den vielfach angeführten Enaminmechanismus. Durch die Umsetzung von Isatinen gelingt die enantioselektive Synthese biologisch aktiver 3-Hydroxyindolin-2-one. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.