Organoaluminum‐Mediated Direct Cross‐Coupling Reactions

Abstract

Abstract We present a direct cross‐coupling reaction between arylaluminum compounds (ArAlMe 2 ⋅LiCl) and organic halides RX (R=aryl, alkenyl, alkynyl; X=I, Br, and Cl) without any external catalyst. The reaction takes place smoothly, simply upon heating, thereby enabling the efficient and chemo‐/stereoselective formation of biaryl, alkene, and alkyne coupling products with broad functional group compatibility.