Obstetrics and Gynecology · 2013 · 223 citations · 0 references
MedicineMaternal HealthObstetricsHigh-risk PregnancyMaternal-fetal MedicinePrenatal DiagnosisPregnancyThromboembolic DiseaseThromboembolism PreventionThrombosisThrombotic DisordersVenous ThromboembolismGenetic ThrombophiliaPregnancy-associated Venous ThromboembolismThromboembolic Complications In PregnancyThrombophilia In PregnancyThrombophilia Risk AssessmentThrombosis Prevention In PregnancyVenous Thromboembolism DetectionVenous Thromboembolism Diagnosis
Inherited thrombophilias are associated with an increased risk of venous thromboembolism and also have been linked to adverse outcomes in pregnancy. However, there is limited evidence to guide screening for and management of these conditions in pregnancy. The purpose of this document is to review common thrombophilias and their association with maternal venous thromboembolism risk and adverse pregnancy outcomes, indications for screening to detect these conditions, and management options in pregnancy.