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Detection of early tumor response to Abraxane using H-scan imaging: Preliminary results in a small animal model of breast cancer
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2017
Year
Medical UltrasoundEngineeringOncologic ImagingAdvanced ImagingRelative SizeBiomedical EngineeringDiagnostic ImagingH-scan ImagingOncologyBreast ImagingRadiation OncologyNuclear MedicineCancer ResearchRadiologyFocused UltrasoundMedical ImagingNew UltrasoundUltrasoundMedical Image ComputingEarly Tumor ResponseBiomedical ImagingBreast CancerMedicine
H-scan is a new ultrasound (US) technique that images the relative size of acoustic scatterers. This modality relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials (GWHP). Parallel convolution filters using the second (GWH2) and eighth (GWH8) components are applied to the radio frequency US data to capture the low and high frequency signal components respectively. The relative strength from each convolution is color-coded and imaged. The purpose of this study was to evaluate the potential of H-scan imaging for characterizing tumor tissue in an animal model and any early response to systemic anticancer treatment.