Enantioselective Total Synthesis of the Marine Toxin (−)‐Gymnodimine Employing a Barbier‐Type Macrocyclization

Abstract

Exoten des Meeres: tert-Butyllithium vermittelt bei Umgebungstemperatur eine Barbier-Makrocyclisierung in der ersten Totalsynthese von (−)-Gymnodimin (Ts: Toluol-4-sulfonyl; TBS: tert-Butyldimethylsilyl), einem marinen Toxin aus der Familie der spirocyclischen Imine. Die Synthese enthält außerdem eine vinyloge Mukaiyama-Aldolreaktion zur Kupplung der labilen Butenolidgruppe an eine makrocyclische Keton-Zwischenstufe. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.