2016 · 10 citations · 0 references
Life SciencesBioinformaticsGeneticsGenomic Data AnalysisGenomicsSequence AnalysisDna SequencingHaplotype AnalysisNext-generation SequencingVariant AnalysisVariant CallingVariant DetectionBenchmark AnalysisBenchmark DatasetsBioinformatics Pipelines For GenotypingHaplotype-aware Variant CallingHaplotype-based Variant DetectionSpeedVariant BenchmarkingVariant Calling From Alignments
Sentieon DNA Software is a suite of tools that allow running DNA sequencing secondary analysis pipelines. The Sentieon DNA Software produces results identical to the Genome Analysis Toolkit (GATK) Best Practice Workflow using HaplotypeCaller, with more than 20x increase in processing speed on the same hardware. This paper presents a benchmark analysis of both speed comparison and output concordance between using GATK and Sentieon DNA software on publically available datasets from the 100 genomes database.