BMJ · 1975 · 28 citations · 3 references
MedicineOncologyPharmacologyChemotherapyMedical OncologyOncology PharmacotherapyChemotherapy In Hematologic MalignanciesCombination ChemotherapyHodgkin Lymphoma TherapyHodgkin Lymphoma TreatmentLymphoma ChemotherapyPrednisolone UsePrednisone Use
A combination of mustine, vincristine (Oncovin), procarbazine, and prednisione (MOPP) and the same combination without prednisone (MOP) were compared in the treatment of stage IV Hodgkin's disease in a prospective randomized trial. The complete remission rates were 80% with MOPP and 44% with MOP; the difference was highly significant. Prednisone seems to be an important component of the MOPP combination in the management of stage IV Hodgkin's disease.
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