Design and Synthesis of Minimalist Terminal Alkyne‐Containing Diazirine Photo‐Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell‐ and Tissue‐Based Proteome Profiling

Abstract

Klein und zackig: Nach der Einführung eines minimalen Photovernetzers mit Eignung für Klick-Reaktionen (siehe Schema) in zahlreiche niedermolekulare Kinase-Inhibitoren wurden die resultierenden Sonden zum Proteom-Profiling in vitro (in Zelllysaten) und in situ (in lebenden Zellen) eingesetzt. Auch bei der Identifizierung ihrer potenziellen Zielkinasen im großen Maßstab waren sie bekannten Sonden überlegen. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.