Targeted Charge‐Reversal Nanoparticles for Nuclear Drug Delivery

Abstract

Reversing the charges: Targeted charge-reversal nanoparticles (TCRNs) comprised of poly(ε-caprolactone)-block-polyethyleneimine (PCL-PEI), whose amine groups are converted into amides, are negatively charged at neutral pH but become positively charged at pH<6 (see picture). TCRNs effectively enter cells, regenerate the PEI layer in lysosomes, and localize in the nucleus for nuclear drug delivery. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z605254_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.