Angewandte Chemie · 2017 · 14 citations · 26 references
MedicineMedicinal ChemistryNuclear MedicineMolecular ImagingOncologic Nuclear MedicineTherapeutic Nuclear MedicineMolecular Imaging In OncologyPositron Emission TomographyRadiopharmaceutical DesignRadiopharmaceuticalsRadiotracer DevelopmentTumor ImagingComplexation ChemistryIn Vivo ImagingMild Reaction ConditionsMolecular Imaging Probe DesignPet RadiopharmaceuticalsRadiotracer SynthesisSmall Molecule Imaging AgentsTumor Radiotracer Imaging
Abstract Unprecedented fast and efficient complexation of Sc III was demonstrated with the chelating agent AAZTA (AAZTA=1,4‐bis(carboxymethyl)‐6‐[bis(carboxymethyl)]amino‐6‐methylperhydro‐1,4‐diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA) − chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc‐based radiopharmaceuticals using the AAZTA chelator.
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Kinetics of Formation and Dissociation of Lanthanide(III)-DOTA Complexes
Éva Tóth, Ernő Brücher, István Lázár et al. · Inorganic Chemistry · 1994 · 210 citations