Hemodynamic Effects of Isoflurane and Halothane in Patients with Coronary Artery Disease

Abstract

In 12 patients undergoing saphenous vein coronary artery bypass operations cardiovascular hemodynamics were studied in the awake state (control) and during anesthesia with isoflurane (inspired concentration, 1.24%, 7 patients) or with halothane (inspired concentration, 0.77%, 5 patients). Isoflurane anesthesia was accompanied by decreases of 19% in the cardiac in- dex (𝑄̇), 19% in mean arterial pressure and 16% in heart rate (HR). Only the change in was statistically significant. Halothane anesthesia was accompanied by decreases in 𝑄̇ (28%) (22%), and HR (10%). The changes in 𝑄̇ and were significant. HR did not change significantly following the induction of anesthesia with either agent. The decrease in was similar with both agents, and, in this regard, neither agent was clearly superior for patients with occlusive coronary artery disease.