M2 Proton Channel Structural Validation from Full‐Length Protein Samples in Synthetic Bilayers and <i>E. coli</i> Membranes

Abstract

Glaubwürdig: Die Struktur von Membranproteinen hängt von der in der Strukturcharakterisierung verwendeten Umgebung ab. NMR-Spektren des tetrameren M2-Protonenkanals des Influenza-A-Virus wurden direkt in E.-coli-Membranen aufgenommen und mit den Spektren des Proteins in synthetischen Lipiddoppelschichten verglichen. Die Ergebnisse belegen, dass die Doppelschichten eine native Membranumgebung bereitstellen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.