Natural SciencesChemistryMedicinal ChemistryAnesthesiaOrganic ChemistrySynthetic Medicinal ChemistryAnesthetic PharmacologyMedicinal Chemistry ApplicationsMixed AnhydridesPiperidine SynthesisPyridine ChemistryPyridine Synthesis
Abstract The mixed anhydride method has been used successfully in the synthesis of a series of pyridinecarboxamides. Hydrogenation of some of these products furnished piperidinecarboxarnides which were found to possess excellent local anesthetic properties and low toxicities.
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Local Anesthetics I. N-Alkyl Pyrrolidine and N-Alkyl Piperidine Carboxylic Acid Amides.
Bo af Ekenstam, Börje Egnér, Gösta Pettersson · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1957 · 115 citations · Full text
TRIALS WITH CARBOCAINE: A New Local Anaesthetic Drug
B. AF EKENSTAM, B. EGNER, L.R. ULFENDAHL et al. · British Journal of Anaesthesia · 1956 · 45 citations · Full text
J.M. Mumford, T. Cecil Gray · British Journal of Anaesthesia · 1957 · 17 citations · Full text