Enantioselective<i>ortho</i>‐CH Cross‐Coupling of Diarylmethylamines with Organoborons

Abstract

Abstract The commonly used para ‐nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation of amines for the first time. An enantioselective ortho ‐CH cross‐coupling between nosyl‐protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono‐ N ‐protected amino acid (MPAA) ligands as a promoter.