Total Synthesis of (−)‐Acetylaranotin

Abstract

Der Schlüsselschritt in dieser Totalsynthese von (−)-Acetylaranotin ist die effiziente Bildung des charakteristischen Dihydrooxepinrings aus Cyclohexenon durch eine ungewöhnliche vinyloge Rubottom-Oxidation und regioselektive Baeyer-Villiger-Oxidation. (−)-Acetylaranotin wurde in 22 Stufen aus kommerziell erhältlichem L-Cbz-Tyrosin (Cbz=Benzyloxycarbonyl) erhalten. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.