Switchable Motion of DNA on Solid Supports

Abstract

Tracking the changes: The switchable translocation of a nucleic acid strand with a methylene blue (MB+) redox group on a DNA track associated with a surface can be triggered by adenosine monophosphate (AMP, green) and adenosine deaminase (purple, see picture); the latter converts AMP into inosine monophosphate (orange). The motion of the nucleic acid can be followed by the electrochemical, photo-electrochemical, and fluorescence signals.