Low Brain Magnesium in Migraine

Abstract

SYNOPSIS Brain magnesium was measured in migraine patients and control subjects using in vivo 31‐Phosphorus Nuclear Magnetic Resonance Spectroscopy. pMg and pH were calculated from the chemical shifts between Pi, PCr and ATP signals. Magnesium levels were low during a migraine attack without changes in pH. We hypothesize that low brain magnesium is an important factor in the mechanism of the migraine attack.