Direct Catalytic Asymmetric Synthesis of N‐Heterocycles from Commodity Acid Chlorides by Employing α,β‐Unsaturated Acylammonium Salts

Abstract

Asymmetrisch gezähmte Bestie: Die Reaktivität von Säurechloriden last sich mit Chinaalkaloid-Katalysatoren modulieren. Die resultierenden chiralen α,β-ungesättigten Acylammoniumionen reagieren mit Nucleophilen unter enantioselektiver Bildung von Pyrrolidinonen, Piperid-2-onen und Dihydropyridinonen. Die Kaskade ergibt chirale Zwischenstufen bekannter Pharmakasynthesen. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.