Publication | Open Access
A Novel Reductive Amino Cyclization Method and Its Application for the Syntheses of Pyrrolidine and Piperidine Nucleus
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1986
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HeterocyclicBiochemistryNatural SciencesDrug DiscoveryDiversity-oriented SynthesisMedicineCactus AlkaloidPiperidine DerivativesPeptide SynthesisOrganic ChemistryNovel Synthetic MethodHeterocycle ChemistryPharmacologySynthetic ChemistryBiomolecular EngineeringPiperidine NucleusNatural Product Synthesis
A novel synthetic method for pyrrolidine and piperidine derivatives is developed.Its versatility is proved by the syntheses of 6a,9a-e-6,6a,7,8,9,9a-hexahydro-25-iso- indolol4,5,6-cdlindole and cactus alkaloid, (?)-lophocerine.