Concepedia

An Efficient Synthesis of 3-Hydroxy-3-Trifluoromethyl Phthalide

Donald A. Shaw, Terrence C. Tuominen

Synthetic Communications · 1985 · 11 citations · 2 references

DOI

Concepts

Abstract

An efficient synthesis of 5 is described. Conversion of bromotoluene 1 to trifluoromethylacetophenone 2 followed by a benzylic oxidation-cyclization protocol afforded the target phthalide 5.

References

2

Fluoro ketone inhibitors of hydrolytic enzymes

Michael H. Gelb, John Svaren, Robert H. Abeles · Biochemistry · 1985 · 339 citations

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Regiospecific synthesis of aromatic compounds via organometallic intermediates. 4. Synthesis of ortho-disubstituted benzenes

Usha Prabhu, Kalathil C. Eapen, Christ Tamborski · The Journal of Organic Chemistry · 1984 · 30 citations

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