Angewandte Chemie · 2019 · 147 citations · 31 references
Natural SciencesChemistryMaterials ScienceCatalysisNanomaterialsNanotechnologyCarbon NanomaterialsCatalyst DesignNanobiomaterialsNanocatalysisNanomedicineSurface Functionalization Of NanomaterialsAtomically Dispersed CatalystsCatalyst Structure - Activity RelationshipsCatalytic NanomaterialsEnzymatic Catalysis MechanismsEnzyme Catalytic MechanismSingle-atom CatalysisSingle-atom CatalystsTheoretical Modeling Of Nanocatalysts
Abstract Single‐atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic catalysis. Herein, we report that a zinc‐based zeolitic‐imidazolate‐framework (ZIF‐8)‐derived carbon nanomaterial containing atomically dispersed zinc atoms can serve as a highly efficient single‐atom peroxidase mimic. To reveal its structure–activity relationship, the structural evolution of the single‐atom nanozyme (SAzyme) was systematically investigated. Furthermore, the coordinatively unsaturated active zinc sites and catalytic mechanism of the SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme, with high therapeutic effect and biosafety, shows great promises for wound antibacterial applications.
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