Palladium(0)‐Catalyzed Intermolecular Carbocyclization of (1,<i>n</i>)‐Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds

Abstract

Abstract A novel palladium(0)‐catalyzed dearomative cyclization reaction of bromophenols with (1, n )‐diynes has been developed for building two new types of tricyclic architectures containing a quaternary carbon center. This method employs inexpensive bromophenols, and easily accessible tethered diynes. It exhibits a broad substrate scope and tolerates various functional groups. Preliminary results with commercially available chiral ligands indicate that enantioselective variants are feasible for both cyclization processes.