Protein–DNA Recognition Triggered by a DNA Conformational Switch

Abstract

Making the switch: The analysis of molecular dynamics simulations of the SRY-protein–DNA complex shows that, when the SRY protein approaches the correct DNA target sequence, it triggers a DNA conformational switch and allows the passage from a nonspecifically bound to a specifically bound state (see picture; dAXC=distance between DNA and SRY protein). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.