A New Solid‐Phase Reaction System Utilizing a Temperature‐ Responsive Catalyst: Oxidative Cyclization with Hydrogen Peroxide

Abstract

Abstract A switchable catalyst based on temperature change provides a novel solid‐phase reaction system in water. An increase in catalyst affinity for organic substrates at higher temperature led to efficient activity driving the solid inner‐phase reaction, and loss of affinity at lower temperature allowed easy separation of organic products upon completion of the reaction. Application of this catalyst intelligence to design a novel catalytic system brought about an efficient oxidative cyclization with hydrogen peroxide, a useful method of accessing oxygen heterocycles.