Concepedia

A Heterobimetallic Pd/La/Schiff Base Complex for <i>anti</i>‐Selective Catalytic Asymmetric Nitroaldol Reactions and Applications to Short Syntheses of β‐Adrenoceptor Agonists

Shinya Handa, Keita Nagawa, Yoshihiro Sohtome, Shigeki Matsunaga, Masakatsu Shibasaki

Angewandte Chemie · 2008 · 45 citations · 43 references

DOI

Concepts

Abstract

Passgenau für zwei Metalle: Die Kombination aus Pd und La in einem Schiff-Base-Liganden führt zu einer anti-selektiven katalytischen asymmetrischen Nitroaldolreaktion (siehe Schema). Mithilfe des Heterodimetallkatalysators gelingen kurze Synthesen von β-Adrenozeptor-Agonisten.

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