Ruthenium Oxidase Catalysis for Site‐Selective C–H Alkenylations with Ambient O₂ as the Sole Oxidant

Abstract

Abstract Ruthenium(II) oxidase catalysis by direct dioxygen‐coupled turnover enabled step‐economical oxidative CH alkenylation reactions at ambient pressure. Versatile ruthenium(II) biscarboxylate catalysts displayed ample substrate scope and proved applicable to weakly coordinating and removable directing groups. The twofold CH functionalization strategy was characterized by exceedingly mild reaction conditions as well as excellent positional selectivity.