The immediate vicinity of mouse metallothionein‐I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter

Abstract

Glucocorticoid responsive elements (GREs) located −252 to −209 bp upstream and +1011 to +1054 bp downstream of the transcription initiation site of the mouse metallotionein‐I (mMT‐I) gene were identified in transient transfection eperiments. However, the promoter region of the mMT‐I gene (−330 to +70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.