European Journal of Cancer Prevention · 1992 · 37 citations · 0 references
MedicineOncologySurgeryGastroenterologyGastrointestinal OncologyNeoplasiaEsophageal CancerEsophageal DiseasesEsophageal SurgeryGastroesophageal Reflux DiseaseGastrointestinal NeoplasmsSquamous Cell CarcinomaAdenocarcinoma Of The EsophagusBarrett Esophagus DysplasiaBarrett Esophagus SurgeryEsophageal PathologyGastrointestinal MalignancyModerate DysplasiaReflux EsophagitisSevere Dysplasia
Barrett's oesophagus or columnar lined epithelium of the oesophagus (CLO) is a metaplastic condition associated with excessive gastro-oesophageal reflux. It is found in 15% of patients with reflux oesophagitis. In a detailed study of 115 CLO patients dysplasia was found in 46%; 13.9% were moderate or severe dysplasia, usually found in intestinal type CLO. Fifty patients were endoscoped annually to determine the natural history of the disease. The incidence of adenocarcinoma was 1 in 52 patient-years, a 125-fold excess risk. A dysplasia-carcinoma sequence was seen in the five who developed carcinoma. Patients with early carcinoma were treated surgically with 12% postoperative mortality and 100% survival for 24-70 months.