Screening of antifungal antibiotics according to activities inducing morphological abnormalities.

Abstract

Activities of various known antifungal antibiotics known to induce morphological abnormalities of fungi and yeasts were examined. The observations seemed to provide a standard for detecting new antifungal antibiotics with a selective mode of action. Three new antibiotics, AC549, ATS1287 (leptomycin) and AM630 (fosfazinomycin), were found according to their activities to induce characteristic morphological changes of test organisms. AC549 seemed to be a compound related to gougeroxymycin.