Journal of Applied Biomedicine · 2007 · 94 citations · 37 references
Life SciencesBiochemistryPharmacologyBiochemical PharmacologyMetabolismRedox BiochemistryAnemiaAntioxidant DefenseOxidative Damage To BiomoleculesReactive Oxygen SpeciesRed Blood Cell DisordersRed Blood Cell PhysiologyBlood Cell DisordersHemolysis MechanismsMembrane SkeletonOxidative Degradation ProductsOxidative Degradation StudiesOxidative Membrane InjuryRed Blood Cell Antioxidant DefenseRed Blood Cell Hemolysis
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
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