Studies on the antimicrobial activity of new compounds containing thiourea function

Abstract

New 2-((4-methylphenoxy)methyl)-N-(arylcarbamothioyl)benzamides, prepared from 2-(4- methyl-phenoxymethyl)benzoyl chloride via isothiocyanate formation followed by treatment with various substituted amines, were tested for their antimicrobial features. Despite their weak antimicrobial activity, some of the tested derivatives inhibited the microbial biofilm development on the inert substrata, encouraging further studies of their potential application as anti-biofilm agents.