Synthesis of Enantiomerically Enriched Imidazolidin‐2‐Ones through Asymmetric Palladium‐Catalyzed Alkene Carboamination Reactions

Abstract

Positiver Wassereffekt: Ein Katalysator aus [Pd2(dba)3] (dba=Dibenzylidenaceton) und (S)-Siphos-PE bewirkt die enantioselektive Kupplung von N-Allylharnstoffen mit Arylbromiden zu 4-substituierten Imidazolidin-2-onen. Zusätze von Wasser führen zu deutlich erhöhten Enantioselektivitäten mit elektronenarmen Arylhalogenidsubstraten. Es wird vermutet, dass die reduktive Eliminierung unter C-C-Bindungsbildung der enantioselektive Schritt dieser Reaktionen ist. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.