Journal of the Intensive Care Society · 2012 · 68 citations · 0 references
MedicineInfectious DiseasesPediatricsPediatric Emergency MedicinePediatric Infectious DiseasesSepsisChild MortalityFluid ResuscitationIntensive Care MedicinePediatric SepsisSepsis ManagementSeptic ShockFluid Bolus ChallengeFluid Bolus TherapyImpaired Tissue PerfusionIn-hospital Pediatric ResuscitationPediatric Fluid TherapyPediatric Sepsis MortalitySepsis Fluid ManagementSepsis Fluid Resuscitation
In a large group of critically ill African children, fluid boluses significantly increased 48-hour mortality. The results were most marked in those with haemoglobin levels less than 5 g/dL. The results do not support the routine use of bolus resuscitation in severely ill febrile children with impaired perfusion in African hospitals. Level of evidence: 1B: individual randomised control trial with narrow confidence intervals.