Journal of Veterinary Internal Medicine · 2001 · 55 citations · 11 references
MedicineHematologyPathologyClinical ImmunologyHematopathologyImmunopathologyBone Marrow PathologyEosinophilic DisordersHematologic PathologySerum Specific Immunoglobulin E TestingCytogenetic AberrationsEosinophilic InfiltratesHypereosinophilic SyndromeKaryotypic AbnormalitiesKaryotypic Abnormality DetectionPeripheral EosinophiliaSerum Total Immunoglobulin ETissue Eosinophilia
Abstract Three Rottweilers with marked peripheral eosinophilia and infiltration of the liver, spleen, lungs, and bone marrow with eosinophils were diagnosed with idiopathic hypereosinophilic syndrome (IHES). Mean serum immunoglobulin E concentrations were markedly high. On cytogenetic analysis, no evidence of karyotypic abnormalities was found in bone marrow aspirates. Despite an extensive search, no underlying cause for the eosinophilia could be identified. In this study, cytogenetic analysis and measurement of serum IgE concentrations were used to differentiate IHES and eosinophilic leukemia.
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