Asymmetric Synthesis of 1-Methyl-2-(2-hydroxyethyl)pyrrolidine

Abstract

An asymmetric synthesis of I-methyl-2-(2-hydroxyethylj pyrrolidlne based on optically active I-phenylethylamine is described.The R(+)-enantiomer of 1-methyl-2-(2-hydroxyethy1)pyrrolidine 1 is an important intermediate in the synthesis of the antihistaminic drug Clemastine : A number of syntheses of the optically active forms of this aminoalcohol have been described, mainly in the patent literature.Most of them rely upon resolution