Solvent‐Dependent Enantiodivergent Mannich‐Type Reaction: Utilizing a Conformationally Flexible Guanidine/Bisthiourea Organocatalyst

Abstract

Beachte das Medium: Malonate und tert-Butoxycarbonyl(Boc)-geschützte Imine reagieren in Gegenwart des flexiblen Katalysators 1 je nach Lösungsmittel zu den S- oder R-Addukten. Eine kinetische Analyse dieser enantiodivergenten Organokatalyse erklärt das Verhalten mit einer Enthalpie-Entropie-Kompensation. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.