GenBank

Eric W Sayers, Mark Cavanaugh, Karen Clark, James Ostell, Kim D. Pruitt, Ilene Karsch‐Mizrachi

Nucleic Acids Research · 2019 · 400 citations · 5 references

DOIFull text

Open access

Concepts

TL;DR

GenBank (R) is a comprehensive sequence database containing publicly available DNA sequences from over 119,000 organisms, submitted by individual laboratories and large‑scale projects, and is accessible through NCBI’s Entrez system which integrates sequence, taxonomy, genome, mapping, protein structure, domain information, and PubMed literature, with BLAST providing sequence similarity searches. Submissions to GenBank are made via the BankIt web interface or Sequin programs, with accession numbers assigned by GenBank staff, and daily data exchange with EMBL and the DNA Data Bank of Japan ensures worldwide coverage. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. Access GenBank and its related retrieval and analysis services at http://www.ncbi.nlm.nih.gov.

Abstract

GenBank (R) is a comprehensive sequence database that contains publicly available DNA sequences for more than 119 000 different organisms, obtained primarily through the submission of sequence data from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in the UK and the DNA Data Bank of Japan helps ensure worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, go to the NCBI home page at: http://www.ncbi.nlm.nih.gov.

References

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