Combining NHC–Cu and Brønsted Base Catalysis: Enantioselective Allylic Substitution/Conjugate Additions with Alkynylaluminum Reagents and Stereospecific Isomerization of the Products to Trisubstituted Allenes

Abstract

Vollständig katalytische Route zu trisubstituierten Allenen: Die ersten Beispiele katalytischer enantioselektiver allylischer Substitutionen unter Beteiligung von Alkin-Nucleophilen führen zu Produkten mit tertiären stereogenen Zentren. Die anschließende stereospezifische aminkatalysierte Isomerisierung ergibt trisubstituierte Allene (siehe Bild, NHC=N-heterocyclisches Carben). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.