One-Pot Synthesis of Tetra- and Pentasaccharides from Monomeric Building Blocks Using the Principles of Orthogonality and Reactivity Tuning

Abstract

Tuning the reactivity of glycosyl donors, by selective introduction of different protecting and leaving groups, in conjunction with the principle of orthogonal activation enabled highly efficient oligosaccharide synthesis. One-pot sequential glycosidation of four or five components gave tetrasaccharides and pentasaccharides respectively.