Concepedia

Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes

Yujiro Hayashi, Hiroaki Gotoh, Takaaki Hayashi, Mitsuru Shoji

Angewandte Chemie · 2005 · 459 citations · 29 references

DOI

Concepts

Abstract

Die direkte, katalytische, asymmetrische Michael-Addition von Aldehyden an Nitroolefine in Gegenwart eines chiralen Diphenylprolinolsilylether-Organokatalysators (siehe Schema) liefert hoch syn-diastereoselektiv die gewünschten 1,4-Addukte in nahezu optisch reiner Form und guter Ausbeute. TMS=Trimethylsilyl.

References

29

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