European Journal of Organic Chemistry · 2010 · 17 citations · 23 references
PharmacyChemistryMedicinal ChemistrySynthetic Medicinal ChemistryMacrocycle SynthesisChemical Synthesis Of AnaloguesHeterocycle Functionalization
Abstract The yields of ester‐functionalised Tröger's base analogues are dramatically improved by incorporating an electron‐donating group on the aromatic ring and/or enhancing solubility of the aniline unit. In addition to 2,8‐diester compounds, 1,7‐, 3,9‐ and 4,10‐diester‐functionalised Tröger's base analogues have been prepared for the first time.
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