Structure of paecilospirone, a new antibiotic from Paecilomyces.

Abstract

In the course of a screening search for antimicrobial substances against Bacillus subtilis, the new antibiotic, paecilospirone(I), was isolated from the neutral fraction of an ethyl acetate extract of the culture filtrate of a strain of Paecilomyces sp., which was isolated from a soil sample collected in Takatsuki City.1} In this communication, wereport the structural elucidation of paecilospirone(I). A strain of Paecilomyces sp. was cultivated at 28C for 4 days in a medium of glucose (30g), soybean