MedicineInfectious DiseasesPathologyCellular PathologyHematopathologyHistopathologyConnective Tissue DiseasesConnective Tissue DisordersImmunodeficiency DisordersLymph Node PathologyLymphoid TissueLymphoid Tissue PathologyBenign Lymphoid HyperplasiaLymph Node HistologyLymphatic HyperplasiaOptimal Treatment Regimes
Castleman's disease is characterized by a non-clonal lymph node hyperplasia. Pathologically it is classified as hyaline vascular, plasmacytic, or mixed cellularity types, and clinically it may adopt a unicentric (localized) or multicentric presentation. An association of the disease with HIV infection has been found. Many uncertainties remain concerning the etiopathogenesis and the optimal treatment of this rare condition.