Total Synthesis of Pentabromo‐ and Pentachloropseudilin, and Synthetic Analogues—Allosteric Inhibitors of Myosin ATPase

Abstract

Eine hoch effiziente Silber(I)-katalysierte Cyclisierung von N-Tosylhomopropargylaminen ermöglicht die Totalsynthesen der Titelverbindungen. Die Pseudilin-Derivate sind neuartige Myosin-Inhibitoren. Für Pentabrompseudilin (1) wurde anhand einer Röntgenstrukturanalyse des Inhibitor-Protein-Komplexes eine neue allosterische Bindungstasche in der Dictyostelium-Myosin-2-Motordomäne identifiziert. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.