Publication | Closed Access
Saturated Bioisosteres of <i>ortho</i>‐Substituted Benzenes
22
Citations
51
References
2020
Year
Medicinal ChemistryAntifungal AgentBioorganic ChemistryHeterocyclicAntifungal ActivityNatural SciencesOrganic ChemistrySaturated BioisosteresChemistrySaturated AnaloguesAbstract Saturated BioisosteresPharmacologyHeterocycle ChemistryPharmaceutical ChemistrySynthetic Chemistry
Abstract Saturated bioisosteres of ortho ‐disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad .
| Year | Citations | |
|---|---|---|
Page 1
Page 1