Concepedia

Ru‐Catalyzed Anti‐Markovnikov Addition of Amides to Alkynes: A Regio‐ and Stereoselective Synthesis of Enamides

Lukas J. Gooßen, Jan E. Rauhaus, Guo‐Jun Deng

Angewandte Chemie · 2005 · 46 citations · 25 references

DOI

Concepts

Abstract

Die basenfreie Anti-Markownikow-Addition von sekundären Amiden, Aniliden, Lactamen, Harnstoffderivaten, Bislactamen und Carbamaten an terminale Alkine gelingt erstmalig durch eine rutheniumkatalysierte Reaktion. Zwei komplementäre Protokolle führen jeweils stereoselektiv zu den E- oder Z-Isomeren (siehe Schema; cod=Cycloocta-1,5-dien; DMAP=4-(N,N-Dimethylamino)pyridin).

References

25

Catalytic Markovnikov and anti‐Markovnikov Functionalization of Alkenes and Alkynes: Recent Developments and Trends

Matthias Beller, Jayasree Seayad, Annegret Tillack et al. · Angewandte Chemie International Edition · 2004 · 1.1K citations · Full text

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Monodentate Phosphoramidites: A Breakthrough in Rhodium‐Catalysed Asymmetric Hydrogenation of Olefins

Michel van den Berg, Adriaan J. Minnaard, Robert M. Haak et al. · Advanced Synthesis & Catalysis · 2003 · 227 citations

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CuI/<i>N</i>,<i>N</i>-Dimethylglycine-Catalyzed Coupling of Vinyl Halides with Amides or Carbamates

Xianhua Pan, Qian Cai, Dawei Ma · Organic Letters · 2004 · 225 citations

, , +8

A Three-Step Procedure for Asymmetric Catalytic Reductive Amidation of Ketones

Mark J. Burk, Guy Casy, Nicholas Johnson · The Journal of Organic Chemistry · 1998 · 206 citations

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Palladium-Catalyzed Amidation of Enol Triflates:  A New Synthesis of Enamides

Debra J. Wallace, David J. Klauber, Cheng‐yi Chen et al. · Organic Letters · 2003 · 162 citations

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