Cytotoxic Effects of Valsartan Organotin(IV) Complexes on Human Lung Cancer Cells

Abstract

The organotin(IV) compounds used in chemotherapy due to its lipophilicity, affected by the number of carbon atoms and the cytotoxicity. These are affected by the obtainability of Sn coordination bond and bond stabilization between ligand and tin. Two novel organotin(IV) complexes were synthesized, characterized, and tested against human lung cancer cells (A549). The cytotoxic effect of the prepared organotin(IV) complexes against human lung cancer cells (A549) was investigated using the MTT colorimetric assay. Apoptosis was investigated by flow cytometry. The cytotoxicity assay reveals that the Bu2SnL2 complex is more active to inhibit the growth of A549 cells compared to the Ph2SnL2, and doxorubicin, nevertheless at high concentration (50 and 100) µg/mL the doxorubicin was more affective to inhibit the viability of A549 cells.