Journal of the American Statistical Association · 1978 · 117 citations · 0 references
Public HealthBiostatisticsExperimental DesignExperimental EconomicsMarkov Decision ProcessesClinical TrialsOptimal StoppingRandomized Controlled TrialsSequential ExperimentationTreatment AssignmentTrial Sequential AnalysisPlay-the-winner RuleRandomized AssignmentSequential Clinical Trial DesignTreatment Allocation
Abstract In a sequential medical trial, a simple randomized treatment assignment rule is proposed and analyzed. On the average this rule assigns more patients to the better treatment, and it is applicable to the case where patients have delayed responses to treatments. This new assignment rule is studied for both a fixed sample size and an inverse stopping rule.