MedicineBiochemistryPharmacologyBiochemical PharmacologyClinical PharmacologyGeneral PharmacologyAnthelmintic PharmacologyCholesterol MetabolismDrug MonographsAtherosclerosis RiskBiological Activity FeaturesDrug CompendiaHistory Of PharmacologyStereochemical Structure - Activity RelationshipTherapeutic Drug Monographs
The first 2 volumes of this annual were reviewed here last year (<i>JAMA</i><b>178</b>:684 [Nov. 11] 1961). Its function is to provide review monographs with extensive bibliographies of certain classes of drugs, as well as a brief description of drugs introduced during the past year. The articles are in English, French, and German and intended more for scientists than physicians. The articles in English first discuss the relation of chemical structure and activity of some anthelmintics in which the various techniques of testing such compounds in vitro and in vivo are discussed critically; phenothiazine and piperazines, their metabolites and numerous related compounds are compared in activity. Both types may act by paralysis of the neuromuscular junction and inhibition of mitochondrial enzymatic metabolism. The detailed chemical discussions will provide rather heavy going for the average physician as they did for the reviewer. The comprehensive review of 5-hydroxytryptamine (serotonin) and related