Statistics in Medicine · 1996 · 64 citations · 0 references
Veterinary MedicineBiostatisticsInfectious DiseasesEpidemiologyInfectious Disease EpidemiologyVirologySerological DiagnosisSeroprevalence StudiesViral EpidemiologyAge-specific DistributionDisease Prevalence SurveysInfectious Disease SerologyMaximum Likelihood InferencePopulation SerologyPopulation SerosurveysSerological DetectionSerological Epidemiology
A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.